This analysis identifies cytokines in the IL-23/IL-17 axis, linking them to cirrhosis complications, highlighting systemic inflammation.
Background and Objective: Acute decompensation (AD) and acute-on-chronic liver failure (ACLF) are major complications of cirrhosis, often leading to multi-organ dysfunction. The IL-23/IL-17 cytokine axis plays a critical role in driving systemic inflammation and immune dysregulation in various chronic diseases. However, its precise role in cirrhosis and its progression to ACLF remains poorly understood. This study aimed to investigate the significance of circulating cytokines involved in the IL-23/IL-17 axis and their association with clinical phenotypes of cirrhosis, including AD and ACLF.
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Konstantis et al. (2025) studied this question.
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