The transcription factor AP-1 as a treatment option for patients with colorectal adenocarcinoma

Background: The Activator Protein-1 (AP-1) transcription factors are expressed in many cancer entities and are correlated to deregulated transcription factor networks including dedifferentiation and therapy resistance. They are involved in key functions of the cellular biology and maintain and adjust the transcriptional networks leading to transformation and malignancy. Colorectal cancer is despite novel therapy approaches still one of the deadliest malignancies with a huge number of yearly cancers deaths. Especially once the primary tumor has spread, the overall survival of the patients is poor. There is an urgent need for better patient stratification to increase the outcome of the multimodally treated patients.