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September 10, 2025Open Access

Obesogenic Diet Impairs Social Memory Through Alterations of Hippocampal CA2 Excitability and Oxytocin Signaling

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Authors

MMMaud MullerAFAlice FermigierEDEva‐Gunnel Ducourneau

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Overview

Mice fed an obesogenic diet showed impaired social memory, indicating oxytocin's role in hippocampal CA2 signaling.

Key Points

  • Social memory deficits arose from impaired hippocampal CA2 excitability due to high-fat and sugar diets.
  • HFD resulted in increased action potential firing in CA2 neurons; chemogenetic inhibition mitigated memory deficits.
  • Oxytocin receptor activation in CA2 led to abnormal excitability in HFD-fed mice, disrupting memory plasticity.
  • The findings reveal a novel link between diet, oxytocin signaling, and social memory encoding mechanisms.

Cite This Study

Muller et al. (2025) studied this question.

synapsesocial.com/papers/68c1954e9b7b07f3a0618a2dhttps://doi.org/10.1101/2025.09.02.673707
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