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Case report highlights dermatologic complications of long-term penicillamine therapy in Wilson disease, suggesting the need for awareness among clinicians.
We report a rare case of coexisting elastosis perforans serpiginosa and acquired cutis laxa in a patient with Wilson’s disease following prolonged penicillamine therapy. This represents two rare but important dermatologic complications of long-term chelation therapy that clinicians should be aware of, given the potential for underlying elastin disruption to also affect systemic tissues.
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Ma et al. (2025) studied this question.
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