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Randomized controlled trial reveals hypothermic oxygenated machine perfusion improves bile composition after liver transplantation, indicating potential protective effects against biliary damage.
Background and aims: In liver transplantation, bile acid toxicity is associated with damage to both hepatocytes and cholangiocytes. End-ischemic hypothermic oxygenated machine perfusion (HOPE) mitigates ischemia-reperfusion injury (IRI) and prevents biliary damage. However, its impact on bile composition remains unclear, as bile samples are typically unavailable after transplantation, resulting in a lack of evidence ([Abb. 1] [2] [3]).
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Schliephake et al. (2025) studied this question.
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