Reduced representation DNA sequencing highlights risk of oesophagus adenocarcinoma in Barrett’s patients, suggesting enhanced surveillance protocols.
Introduction: Barrett's oesophagus (BO) is a precursor lesion for oesophageal adenocarcinoma (OAC). BO diagnosis significantly increases the risk of OAC diagnosis, however the absolute risk of BO to OAC progression is 0.3% per year. As a result, patients with BO diagnosis enter clinical surveillance that includes regular oesophagogastroduodenoscopy (OGD) with biopsies and pictures taken.
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Claussen et al. (2025) studied this question.
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