Analysis reveals that impaired serine metabolism worsens inflammation in IBD, linking C/EBPβ and NF-κB pathways.
Background: Inflammatory Bowel Disease (IBD) is characterized by chronic inflammation and metabolic dysregulation in the intestinal epithelium. Serine, a non-essential amino acid synthesized via the rate-limiting enzyme phosphoglycerate dehydrogenase (PHGDH), maintains cellular redox balance. Serine metabolism is upregulated in cancer and immune cells, supporting survival and growth. However, the mechanism of how PHGDH-related serine metabolism influences the IBD process remains unclear.
No takes yet. Share an insight, caveat, or question.
Yang et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: