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September 10, 2025Diseases of the Esophagus

Neoadjuvant Chemoimmunotherapy Versus Chemotherapy Plus Esophagectomy for Esophageal Squamous Cell Carcinoma: Primary Result of a Randomized Clinical Trial

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BLBin Li

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Overview

Randomized clinical trial compares event-free survival in patients receiving neo-adjuvant chemoimmunotherapy versus chemotherapy, suggesting efficacy of immunotherapy.

Key Points

  • Immunochemotherapy leads to higher rates of pathological complete response in esophageal squamous cell carcinoma.
  • Out of patients treated, 11.7% achieved complete response with immunotherapy, compared to 1.6% with chemotherapy.
  • The trial involved 177 patients, with safety profiles for both treatments considered acceptable.
  • Long-term follow-up is needed to fully assess the survival benefits of neoadjuvant immunotherapy.

Cite This Study

Bin Li (2025) studied this question.

synapsesocial.com/papers/68c195559b7b07f3a0618fe0https://doi.org/10.1093/dote/doaf061.067
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A randomized controlled study on perioperative treatment of esophageal squamous cell carcinoma with camrelizumab combined with nab-paclitaxel and cisplatin.2024
  2. 2Case report: A case study of neoadjuvant immunochemotherapy for locally advanced esophageal squamous carcinoma2024 · 1 citations
  3. 3Neoadjuvant Sintilimab Plus Chemotherapy in Locally Advanced Esophageal Squamous Cell Carcinoma: A Real-World Study2024
  4. 4Survival of esophageal squamous cell carcinoma achieving pathological complete response after neoadjuvant immunochemotherapy2026 · 1 citations
  5. 5Efficacy and safety of neoadjuvant immunotherapy in locally advanced resectable esophageal squamous cell carcinoma: a network meta-analysis and real-world study2026 · 2 citations