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September 10, 2025Postgraduate Medical JournalOpen Access

Genetic causality of circulating inflammatory proteins and plasma metabolites in coronary atherosclerosis

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Authors

RCRunji ChenDSDaifei ShenSWShiwan Wu

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Overview

Mendelian randomization reveals 11 inflammatory proteins and 102 metabolites linked to coronary atherosclerosis, suggesting novel therapeutic targets.

Key Points

  • This analysis identified significant genetic causal relationships between coronary atherosclerosis and circulating inflammatory proteins.
  • Among the identified metabolites, octadecanedioate and campesterol showed a mediation role, with proportions of 18.5% and 26.7%, respectively.
  • Using two-sample Mendelian randomization, the study clarified mechanisms linking inflammation and metabolism to coronary atherosclerosis.
  • The findings highlight potential therapeutic targets that could guide future research and interventions for coronary atherosclerosis.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68c1955c9b7b07f3a061920bhttps://doi.org/10.1093/postmj/qgaf145
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Also Consider

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  1. 1Deciphering the Causal Links: A Mendelian Randomization Study of Circulating Inflammatory Proteins and Cardiovascular Diseases2024 · 1 citations
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  4. 4Plasma proteins and onset of atherosclerosis: integrating human plasma proteogenomics, transcriptomics and in vivo evidence2025 · 3 citations
  5. 5Genetic causal association between lipidomic profiles, inflammatory proteomics, and aortic stenosis: a Mendelian randomization investigation2024 · 2 citations