This approach demonstrates the synthesis of functionalized coumarin-3 derivatives using hydrazines, suggesting a novel method for developing anti-TB compounds.
We demonstrate a direct synthesis of coumarin-3 derivatives from aryl alkynoates and hydrazines in visible light, photocatalyzed by rose bengal. The method is facile, transition-metal-free, versatile, and furnishes various 3-functionalized coumarins such as ester, acyl, aryl, carbamoyl, and sulfonyl in moderate to good yields, with the respective hydrazine reagent serving as the radical precursor. Two anti-TB molecules, 3x and 3y, were synthesized using this method.
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Harsha et al. (2025) studied this question.
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