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September 10, 2025ACS Infectious Diseases

Characterization and Antimicrobial Efficacy of a Bacteriophage Targeting Multidrug-Resistant Escherichia coli

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Authors

TXTianshi XiaoCWChan WangLWLongbo Wang

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Overview

Isolation and characterization of phage vB_EcoM_51 showed lytic activity against multidrug-resistant E. coli, suggesting its potential as phage therapy.

Key Points

  • Phage vB_EcoM_51 significantly improved survival rates in mice infected with multidrug-resistant E. coli.
  • The phage exhibited potent lytic activity against eight E. coli strains and one Salmonella strain.
  • Genome analysis indicated a double-stranded DNA virus classified within the Tequatrovirus genus.
  • Transmission electron microscopy revealed morphological characteristics typical of the Myoviridae family.

Cite This Study

Xiao et al. (2025) studied this question.

synapsesocial.com/papers/68c1955c9b7b07f3a061939dhttps://doi.org/10.1021/acsinfecdis.5c00651
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