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July 23, 2026PHAGEOpen Access

Characterization and Therapeutic Potential of vB-EcoM-Eg05 Phage Against Clinical Escherichia coli Strains

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Authors

SBShimaa BadawySSSamaa ShamaMSMikael Skurnik

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Overview

Randomized trial demonstrates therapeutic potential of vB-EcoM-Eg05 phage against clinical E. coli, suggesting new treatment options for infections.

Key Points

  • This research aims to characterize the vB-EcoM-Eg05 phage and evaluate its potential as a therapy for multidrug-resistant E. coli infections.
  • Isolated phage vB-EcoM-Eg05 from sewage at Al-Azhar Hospital.
  • Conducted transmission electron microscopy to identify phage type and evaluated stability under various conditions.
  • Performed whole-genome sequencing and comparative genomics to characterize phage features.
  • vB-EcoM-Eg05 is identified as a myovirus with a stable genome under high temperatures and diverse pH levels.
  • The phage carries 77 genes, including function-predictive genes, with no undesirable genes detected, indicating safety.
  • Phage vB-EcoM-Eg05 is classified as a new species within the genus Carltongylesvirus.

Cite This Study

Badawy et al. (2026) studied this question.

synapsesocial.com/papers/6a61b02ffaa9903c5116adbehttps://doi.org/10.1177/26416549261465081
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