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September 10, 2025MedicineOpen Access

Association of acute COVID-19 severity and long COVID fatigue and quality of life: Prospective cohort multicenter observational study

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Observational study finds lower quality of life and higher fatigue in mild COVID-19 cases, indicating varied long-term impacts.

Fatigue significantly correlates with anxiety and depression, with physical fatigue showing stronger links, impacting long-term health.
Patients with mild to moderate acute COVID-19 report higher fatigue (17.7 ± 7.2) and lower quality of life compared to severe cases (74.3 ± 20.3).
Observational study conducted across 5 hospitals with longitudinal assessments of fatigue, mental health, and quality of life.
Findings suggest tailored long-term care strategies are needed for individuals with varying acute COVID-19 severity.

Pires et al. (2025) studied this question.

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