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September 10, 2025Journal of BacteriologyOpen Access

Translational coupling of neighboring genes in prokaryotes

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Translational coupling enhances gene expression efficiency when genes are close together.
Coupling efficiency is influenced by RNA secondary structure and the presence of a Shine-Dalgarno sequence.
Two models for coupling have been proposed: the RNA unfolding model and the reinitiation model.
Understanding translational coupling may have important implications for gene regulation in prokaryotic organisms.

Authors

KBKerry M. Brown JWJoseph T. WadeNew York State Department of Health

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Implication

Observational analysis identifies translational coupling between neighboring genes in prokaryotes, suggesting a role for RNA structure in gene expression.

Cite This Study

Brown et al. (2025) studied this question.

synapsesocial.com/papers/68c1956b9b7b07f3a0619b60 https://doi.org/10.1128/jb.00255-25

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Implication

Observational analysis identifies translational coupling between neighboring genes in prokaryotes, suggesting a role for RNA structure in gene expression.

Translational coupling of neighboring genes in prokaryotes

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Discussion

Implication

Cite This Study

Translational coupling of neighboring genes in prokaryotes

Key Points

Discussion

Implication

Cite This Study

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