Biosynthesized Silver Nanoparticles Modulate Inflammation in a Palatine Wound Model

Objectives This study aimed to compare the effects of silver nanoparticles (AgNPs) synthesized with Curcumin ( Curcuma longa L .) or Açai ( Euterpe oleracea ) versus a commercial treatment and photobiomodulation in rat palatal wounds. Methods In vitro cell viability tests assessed nanoparticle toxicity. The animals were initially anesthetized, and circular lesions were created in the palatine mucosa using a 4 mm/diameter punch. The first treatment session commenced 24 h after the injury and continued daily for 5 days. Twenty‐four hours after the final treatment, the animals were euthanized, and the palatal mucosa tissue was collected for histological and biochemical analyses. Results AgNPs‐Cur significantly reduced pro‐inflammatory cytokines and oxidant markers, increased anti‐inflammatory cytokines, the wound contraction rate, and the collagen area, and reduced the inflammatory infiltrate compared to the controls. Conclusion The therapies effectively aided inflammation resolution and accelerated tissue repair. This study highlights potential cost‐effective and efficient alternatives for oral and palatal mucosa wound healing, improving upon standard commercial treatments.