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September 10, 2025Pest Management Science

Insights into the toxicity effects of indoxacarb against Spodoptera frugiperda using metabolomics combined with mass spectrometry imaging

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Authors

LMLianlian MaSouth China Agricultural UniversityXSXuehua ShaoWenzhou Medical UniversityYTYou‐Zhi TangSouth China Agricultural University

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Implication

Observational analysis identified significant changes in metabolites and enzyme activity in Spodoptera frugiperda after indoxacarb exposure, suggesting new insights into pesticide toxicity.

Key Points

  • Indoxacarb treatment showed significant effects on growth and feeding behavior of Spodoptera frugiperda.
  • After 48 hours of exposure, this pest exhibited higher movement and decreased food consumption, indicating metabolic disruption.
  • Using metabolomics and mass spectrometry, spatial distribution of key metabolites demonstrated metabolic dysregulation in the insect.
  • Findings reveal mechanisms of mitochondrial damage and altered amino acid metabolism contributing to the pesticide's toxicity.

Cite This Study

Ma et al. (2025) studied this question.

synapsesocial.com/papers/68c198b59b7b07f3a061a054https://doi.org/10.1002/ps.70195
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