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September 10, 2025Frontiers in Cardiovascular MedicineOpen Access

The role of oxidative stress in modulating mortality risk across the hypertension control cascade

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Authors

WLWeihao LiuCHChunyang HouHWHongjie Wang

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Overview

Cohort study shows lower mortality in hypertensive adults with high oxidative balance scores, suggesting mediation by inflammation.

Key Points

  • Higher oxidative balance scores correlate with reduced all-cause mortality among hypertensive individuals, indicating better health outcomes.
  • Participants in the highest OBS quartile showed a 28% lower all-cause mortality rate compared to the lowest quartile after considering confounders.
  • This cohort study analyzed NHANES data from 1999-2018, exploring oxidative stress and systemic inflammation's role in mortality rates.
  • Findings highlight the importance of oxidative balance in managing hypertension, suggesting potential avenues for improving patient outcomes.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68c198cd9b7b07f3a061ade6https://doi.org/10.3389/fcvm.2025.1621911
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