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September 10, 2025Acta Biochimica Iranica

Aqueous chicory seed extract ameliorates diabetic kidney damage via alteration of renal renin-angiotensin system (RAS) balance

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Authors

SASamin ArdalaniMKMasoumeh KhaliliANAzin Nowrouzi

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Overview

Observational analysis reveals aqueous chicory seed extract ameliorates kidney damage in diabetes, indicating potential therapeutic effects on the renin-angiotensin system.

Key Points

  • Aqueous chicory seed extract improved kidney function by altering the renin-angiotensin system in diabetic rats.
  • In late-stage diabetes, CSE restored AGT and ACE2 levels while reducing ACE activity and collagen content.
  • Early diabetes shows a similar pattern, with CSE enhancing protective angiotensin levels, thereby reducing damage.
  • Both CSE and metformin reduced fibrosis, suggesting their combined therapeutic potential in diabetes.

Cite This Study

Ardalani et al. (2025) studied this question.

synapsesocial.com/papers/68c198cd9b7b07f3a061ade8https://doi.org/10.18502/abi.v3i2.19485
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