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September 10, 2025Acta Biochimica Iranica

Fibroblast Modulation of Invasion and Chemoresistance in Triple-Negative Breast Cancer: Insights from a Two-Cell Organoid Model

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Authors

HAHannaneh AsghariSKShiva A Kbari-Birgani

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Overview

Organoid model shows fibroblasts enhance invasion and reduce drug sensitivity in TNBC, suggesting new targets.

Key Points

  • Fibroblasts significantly enhance invasion and reduce drug sensitivity in triple-negative breast cancer.
  • The study utilized a two-cell organoid model with MDA-MB-231 cells and human foreskin fibroblasts.
  • The findings demonstrate the role of fibroblasts in the tumor microenvironment in modulating TNBC behavior.
  • Targeting fibroblasts could be a promising strategy to overcome chemoresistance in TNBC treatment.

Cite This Study

Asghari et al. (2025) studied this question.

synapsesocial.com/papers/68c198cd9b7b07f3a061ae2ahttps://doi.org/10.18502/abi.v3i2.19486
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