Role of hematologic parameters in predicting early pregnancy loss

Aim: To investigate the role of hematologic parameters in predicting early pregnancy loss (EPL). Materials and Methods: Two hundred eighty-four pregnant women aged between 18 and 45 years who were admitted to our hospital between January 2021-2024 and whose gestational sac measurements were in the 6th-7th weeks, were included in the study. One hundred thirty-three pregnant women who experienced EPL were included in the study group, and the control group consisted of 151 healthy pregnant women who gave birth at ≥37 weeks. Pregnant women who experienced EPL and those who give birth at ≥37 weeks were compared. Age, body mass index (BMI), gravida, parity, abortion, smoking status, and hematologic parameters of all patients were evaluated retrospectively. Results: SII was significantly higher in the EPL group compared with the control group (p=0.044). SIRI was significantly higher in the EPL group compared with the control group (p=0.042). PIV was significantly higher in the EPL group compared with the control group (p=0.048). No significant difference was found in terms of NLR, PLR, MLR, and MPV between the groups. Conclusion: Hematologic parameters such as SII, SIRI, and PIV provide valuable information about inflammatory processes associated with early pregnancy loss. Integration of these parameters into routine prenatal screening protocols may improve the early detection and management of pregnancies at risk of loss. Further studies are needed to determine standard threshold values.