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This is a Meta-Analysis study (also classified as: Systematic Review, Observational).

September 10, 2025Frontiers in MedicineOpen Access

The association of artificial sweeteners intake and risk of cancer: an umbrella meta-analysis

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Artificial sweetener intake shows no significant association with overall cancer risk (RR: 0.99).
Among gynecological cancers, higher intake linked to reduced risk (RR: 0.87), indicating possible protective effects.
The analysis included ten meta-analyses and 35 datasets, enhancing the strength of findings across various study designs.
Sensitivity analyses confirmed the robustness of results, with no publication bias detected in the reviewed studies.

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Umbrella review reveals no significant association between artificial sweeteners and cancer risk, suggesting further research is needed.

Abu‐Zaid et al. (2025) studied this question.

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