Validation of Coronary Wire for the Acquisition of Intracoronary Electrocardiogram in Swine

Background We report the first in‐literature animal experiment to validate the intracoronary ECG signal acquired from a coronary wire compared with the direct signal from an epicardial electrode. Methods An animal model study was performed in a 40 kg pig. Acute myocardial ischemia was induced by intracoronary balloon inflation for 60 s. Simultaneous ECG recording and PCI guidewire electrical and motion measurements were obtained. Results The first ischemic manifestation was myocardial kinetic disturbances, followed by ST‐elevation. The signals recorded from the PCI guidewire and the epicardial electrode ran simultaneously, from the induction of ischemia to complete recovery of signal. Conclusion The intracoronary ECG signal acquired from a coronary wire was equivalent to the direct signal received from an epicardial electrode. Trial Registration: ClinicalTrials.gov identifier: NCT04061525.