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This is a Case Report study (also classified as: Observational).

September 10, 2025Frontiers in OncologyOpen Access

Papillary renal neoplasm with reverse polarity: a case report and literature review

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The case presents a 59-year-old female with a left renal mass diagnosed as papillary renal neoplasm with reverse polarity.
Imaging and surgical evaluation confirmed a 2.1 cm mass with benign characteristics, guided by molecular profiling indicating a KRAS mutation.
Post-operative pathology revealed unique immunohistochemical features, emphasizing the importance of accurate diagnosis for papillary renal cell carcinoma.
Findings suggest potential therapeutic approaches, including immune checkpoint therapy, requiring ongoing research into this rare renal neoplasm.

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Case report identifies distinct features of papillary renal cell carcinoma, highlighting implications for immune checkpoint therapy.

Gonzalez et al. (2025) studied this question.

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