What type of study is this?

September 10, 2025Open Access

Fractional versus standard BNT162b2 boosters after non-mRNA priming in Mongolia: 24-month immunogenicity and safety evidence from a randomised controlled trial

View Full Paper

Ask AI

Bookmark

Authors

TBTsetsegsaikhan BatmunkhNational Center for Communicable Diseases ENEleanor NealMurdoch Children's Research Institute OAOtgonjargal AmraaNational Center for Communicable Diseases

Discussion

Member takes

Implication

Randomised controlled trial shows fractional and standard BNT162b2 boosters provide similar immune responses over 24 months, indicating promising safety profiles.

Key Points

Fractional and standard BNT162b2 boosters maintained similar neutralising activity against SARS-CoV-2 for 24 months, supporting effective long-term immunity.
At 24 months, relative responses between booster types remained comparable, with GMR of 1·06 (95% CI 0·95-1·18), despite some declines.
A total of 601 participants were enrolled, with 520 completing the 24-month follow-up; no COVID-19 hospitalisations occurred throughout the study.
The data suggest fractional boosters can be a cost-effective alternative without compromising immunity or safety.

Cite This Study

Batmunkh et al. (2025) studied this question.

synapsesocial.com/papers/68c199e29b7b07f3a061b3f5 https://doi.org/10.1101/2025.09.04.25335126

View Full Paper

Ask AI

Bookmark

Implication

Randomised controlled trial shows fractional and standard BNT162b2 boosters provide similar immune responses over 24 months, indicating promising safety profiles.

Fractional versus standard BNT162b2 boosters after non-mRNA priming in Mongolia: 24-month immunogenicity and safety evidence from a randomised controlled trial

Discussion

Member takes

Implication

Key Points

Cite This Study

Fractional versus standard BNT162b2 boosters after non-mRNA priming in Mongolia: 24-month immunogenicity and safety evidence from a randomised controlled trial

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider