Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by venous or arterial thrombosis and/or pregnancy outcomes in the presence of persistent antiphospholipid antibodies like lupus anticoagulant (LAC), anti-cardiolipin (aCL), and anti-β2glucoprotein. Antiphospholipid syndrome may occur as a primary disorder or in association with other autoimmune diseases, especially with systemic lupus erythematosus (SLE). This case reports a 28-year-old woman diagnosed with SLE and APS after her first thrombotic event, a deep vein thrombosis (DVT) in the right leg. All SLE patients must be screened for antiphospholipid antibodies, even when thrombotic events have not occurred, to determine the antiphospholipid antibody profile, which is important for future thrombotic risk events.
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