Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025MedicineOpen Access

Exploring multiple myeloma pathobiology and immune cell signatures: Evidence from bidirectional genetic analysis

View Full Paper
Ask AI
Bookmark
Share

Authors

YTYing TianWCWen-Ming ChenYZYue Zhang

Discussion

Loading...

Member takes

Overview

Bidirectional Mendelian randomization reveals immune cell signatures linked to multiple myeloma, suggesting therapeutic targets.

Key Points

  • Significant causal associations between immune cell traits and multiple myeloma risk were identified.
  • Eleven immune cell traits related to three profiles showed strong connections, including CD39 + CD8br %CD8br (P < .001).
  • Bidirectional Mendelian randomization used to analyze immune cell phenotypes and their relationship to multiple myeloma risk.
  • Findings may guide future therapeutic interventions targeting specific immune cells in multiple myeloma.

Cite This Study

Tian et al. (2025) studied this question.

synapsesocial.com/papers/68c199e89b7b07f3a061b795https://doi.org/10.1097/md.0000000000044276
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Circulating immune cells and multiple myeloma: A mendelian randomization study2024
  2. 2Causal Relationship Between Circulating Leukocyte Characteristics and Immune Cell Traits With Multiple Sclerosis Risk: A Two-Sample Bidirectional Mendelian Randomisation Study2026
  3. 3Association of immune cells with the risk of basal cell carcinoma: A bidirectional Mendelian randomized study2025
  4. 4Longitudinal profiling of tumor and immune compartments uncovers patterns of dysregulation and associations with response in multiple myeloma2025
  5. 5Effects of immune cells in mediating the relationship between gut microbiota and myelodysplastic syndrome: a bidirectional two-sample, two-step Mendelian randomization study2024 · 2 citations