The Autologous bone marrow aspirate concentrate injection for the treatment of osteoarthritis: a randomized controlled trial, Ibn-Sina Hospital, NCT05193877 (US registered clinical trial)

Osteoarthritis (OA) is a progressive condition causing symptomatic arthritis in males and females over 45 years, manifested by pain and loss of joint function. The regenerative therapycarry a new insight for treating many orthopedic and sports problemswith minimally invasive procedures to treat osteoarthritis. The bone marrow aspirate concentrate is a possible biological treatment for symptomatic osteoarthritis and chondral defects. Consequently, thisstudy aims to investigate the impact of injection of autologous bone marrow aspiratein the treatment of symptomatic knee osteoarthritis, in addition to assess safety, pain, and functional changes. The current study compriseda randomized controlled trial (RCT) to assess the efficacy of autologous bone marrow aspirate concentrate in the treatment ofsymptomatic knee OA in 30 patients with 55 joints. Two injections were used within 2 months apart. The current results showed a marked drop in the WOMAC score in the intervention arm before and after the injection compared to the control (P-value=0.0001).In conclusion, an improvement ofpain and knee functionwas seen after bone marrow mesenchymal cell njection. The authors recommend extending the following study and treating more patients with knee osteoarthritis with mesenchymal stem cells.