Correlation of Neutrophil To Lymphocyte Ratio and Platelet to Lymphocyte Ratio with High Resolution Computed Tomography in Covid-19 patients

Objective: To correlate the Platelet-to-Lymphocyte Ratio (PLR) and Neutrophil-to-Lymphocyte Ratio (NLR) with Computed Tomography Severity Score (CT-SS) in COVID-19 patients. Study design: Cross sectional analytical study. Place of study: Collaborative study between departments of Physiology, Pathology and Radiology at HITEC-IMS.Duration of study: From June 2020 to December 2021. Patients and methods: A total of 83 (N=83) COVID-19 patients were included in the study through Non-Probability Purposive sampling. They were grouped into mild disease(n=44) and severe disease (n= 39) based on their HRCT severity scores. Their blood samples were obtained and NLR and PLR were correlated with CT-SS using the Spearman's correlation. Results: Data were analyzed by SPSS version 25. Both NLR and PLR showed strong positive correlation with the HRCT severity score (r = 0.471, p < 0.05 for NLR and r = 0.347, p < 0.05 for PLR). Mann Whitney test scores showed that NLR & PLR were significantly different in both the mild and severe disease groups based on HRCT severity scores (p< 0.05). Conclusion: NLR and PLR values could serve as prognostic markers in patients with COVID-19 in place of HRCT.