The Effect of Royal Jelly Administration on the Number of Follicles in Mice (Mus Musculus) Exposed to Noise

This study was aims to prove that royal jelly can affect fertility in terms of maintaining the number of follicles in the folliculogenesis process of mice that are stressed due to noise exposure. This study used 25 female mice aged 2-3 months with a body weight of 20g. Mice were given royal jelly orally for 28 days and then continued with noise exposure of 94dB. Mice were divided into 5 groups consisting of (K-) neither royal jelly nor exposure to noise, group (K+) was not given royal jelly but was given exposure to noise, group was given royal jelly 1.75 mg/days and noise exposure, the group was given royal jelly 3.50 mg/day and noise exposure, and the group was given royal jelly 5.25 mg/day and noise exposure. The results showed that there was no significant difference in the primary and secondary follicles (p>0.05). However, there was a significant difference in tertiary follicles and de Graff follicles between the normal control group without exposure and the group without royal jelly with exposure, the royal dose group jelly 1.75 mg/day, the royal jelly dose group was 3.50 mg/day, but not significantly different from the royal jelly dose group 5.25 mg/day (p<0.05). It can be concluded that a dose of 5.25 mg/day royal jelly can be effectively used in increasing the number of tertiary and deGraff follicles.