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June 20, 2026Journal of Functional Foods0 citationsOpen Access

Royal Jelly Modulates Serotonergic and Inflammatory Pathways to Alleviate Anxiety and Depression

Royal jelly ameliorates anxiety- and depression-like behaviors in ovariectomized mice via modulation of serotonergic and inflammatory pathways

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Authors

MTMomoko TakenakaRNRyota NakanoYYYoshitaka Yamazaki

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Overview

Randomized trial finds royal jelly improves anxiety and depression-like behaviors in ovariectomized mice, suggesting a dietary intervention for menopausal symptoms.

Key Points

  • The aim is to investigate the effects of royal jelly on anxiety and depression-like behaviors in ovariectomized mice and explore the underlying mechanisms.
  • Utilized an ovariectomized mouse model with eight-week-old C57BL/6 J mice.
  • Administered a diet containing 1% royal jelly post-ovariectomy and conducted behavioral assessments.
  • Performed ELISA analysis and transcriptomic analysis to assess serotonin levels and inflammation-related pathways.
  • Royal jelly supplementation significantly improved anxiety-like behaviors in OVX mice.
  • It partially alleviated depression-like behaviors, as indicated by behavioral assessments.
  • ELISA showed a significant increase in serotonin levels in the hippocampus, alongside modulation of inflammatory pathways.

Cite This Study

Takenaka et al. (2026) studied this question.

synapsesocial.com/papers/6a362de1db0793dc1a535defhttps://doi.org/10.1016/j.jff.2026.107382
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