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Synapse
January 23, 2026Compounds1 citationsOpen Access

Royal Jelly Improves Cognitive Decline and Reduces Anxiety in Female Mice

Royal Jelly Mitigates Cognitive Decline and Anxiety in Female Mice: A Promising Natural Neuroprotective Solution for Alzheimer’s Disease

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Authors

NDNoureddine DjebliNMNadjet MostefaHCHadjer Chenini-Bendiab

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Overview

In vivo and in vitro studies reveal royal jelly's potential neuroprotective effects in Alzheimer's female model, suggesting new therapeutic avenues.

Key Points

  • This research investigates the neuroprotective effects of royal jelly on cognitive decline and anxiety in a mouse model of Alzheimer's disease.
  • Conducted in vitro analysis of chemical properties of royal jelly extract.
  • Divided female mice into groups for treatment: control, Alzheimer's, and various doses of royal jelly.
  • Induced Alzheimer's model in mice using aluminum chloride and D-galactose over 45 days.
  • Assessed cognitive and behavioral changes using various maze tests after treatment.
  • Royal jelly improved cognitive deficits and reduced anxiety in Alzheimer's-affected mice.
  • Indicated moderate antioxidant activity with a rich bioactive profile including flavonoids.
  • No toxicity was observed in vivo from royal jelly administration.

Cite This Study

Djebli et al. (2026) studied this question.

synapsesocial.com/papers/69731005c8125b09b0d1fc34https://doi.org/10.3390/compounds6010008
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Royal jelly ameliorates anxiety- and depression-like behaviors in ovariectomized mice via modulation of serotonergic and inflammatory pathways2026
  2. 2Pro-Cognitive Effect of Royal Jelly Is Linked with Increased Burst Activity of Mesocorticolimbic Dopaminergic Neurons2025
  3. 3Investigation of Anti-Alzheimer Activity of Royal Jelly in an in vitro Human Digestive System Model2024
  4. 4Chestnut ‘castanea sativa mill.’ honey potential in preventing memory decline on alzheimer’s disease model mice: in vitro enzyme activities, behavioural, memorial and histopathological studies2024
  5. 5230. CANNABIDIOL MITIGATES COGNITIVE DEFICITS IN A MOUSE MODEL OF ALZHEIMER’S DISEASE2025