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September 10, 2025Regional Anesthesia & Pain Medicine

Comparison of the Hemodynamic Effects of a Single 5 mg/kg Dose of Lidocaine With or Without Epinephrine for Thoracic Paravertebral Block

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Authors

IGIgnacio GaruttiUniversidad Complutense de Madrid LOLuis OlmedillaHospital General Universitario Gregorio Marañón PCpatricia cruzUniversidad Mayor de San Andrés

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Implication

Randomized trial examined hemodynamic effects of lidocaine with or without epinephrine in surgery patients, suggesting that epinephrine reduces adverse outcomes.

Key Points

The addition of epinephrine decreases cardiac contractility reductions caused by systemic lidocaine absorption.
Lid+E group experienced up to 53% lower blood lidocaine levels after 15 minutes, indicating reduced absorption.
Monitoring included cardiac index and hemodynamic variables in 50 patients during lung resection surgery.
Epinephrine's presence may help manage lidocaine's adverse cardiovascular effects, improving patient safety.

Cite This Study

Garutti et al. (2008) studied this question.

synapsesocial.com/papers/68c19aad9b7b07f3a061c2e3 https://doi.org/10.1136/rapm-00115550-200801000-00010

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Implication

Randomized trial examined hemodynamic effects of lidocaine with or without epinephrine in surgery patients, suggesting that epinephrine reduces adverse outcomes.

Comparison of the Hemodynamic Effects of a Single 5 mg/kg Dose of Lidocaine With or Without Epinephrine for Thoracic Paravertebral Block

Discussion

Member takes

Implication

Key Points

Cite This Study

Comparison of the Hemodynamic Effects of a Single 5 mg/kg Dose of Lidocaine With or Without Epinephrine for Thoracic Paravertebral Block

Discussion

Member takes

Implication

Key Points

Cite This Study

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