This review demonstrates advancements in chemotherapy and radiotherapy for retinoblastoma, suggesting improved outcomes for globe preservation.
The management of retinoblastoma has evolved significantly over recent years. Currently treatment aims to preserve the globe as well as vision with minimum morbidity. High resolution imaging has improved tumor detection and is useful for prognosticating cases and monitoring response to treatment. From enucleation to external beam radiotherapy, treatment pattern has significantly shifted to chemotherapy, specifically, targeted chemotherapy such as intra-arterial and intra-vitreal chemotherapy and has shown promising results. Now these routes are being increasingly employed world-wide for globe preservation. Newer radiotherapy techniques has led to improved radiation delivery to the target and more conformal treatment plans with better normal tissue sparing. This review aims to highlight current scenario and newer advancements in the field of diagnosis and management of retinoblastoma with protocol-based treatment plans for better survival as well as globe salvage.
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Ali et al. (2023) studied this question.
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