Chronotherapeutic analgesic effect of Urtica dioica and Indomethacin in Mice

The primary goal of the study was to examine how to lessen indomethacin's negative effects while boosting its analgesic and anti-inflammatory properties. The yield of methanolic Urtica dioica extract during thirteen siphons was 250 gm ±2.68% per 5 gm Urtica dioica . In sixty male mice, control given five was dosed, Urtica dioica given five was dosed with 10,20,40,60, and 80, and indomethacin given five subgroups was dosed with 10, 15, 25,30, and 35 mg. The nociceptive stimulus was realized with analgesia and anti-inflammatory parameters. This study aimed to evaluate the Urtica dioica and indomethacin as an analgesic and anti-inflammatory efficacy and referenced free-form indomethacin in mice.