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The Association Between Injected Volume of Local Anesthetic and Spread of Epidural Anesthesia: A Hypothesis

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Randomized trial examines injected volume's influence on hypesthesia in epidural anesthesia, suggesting a cubic relationship.

The study finds a non-linear relationship between injected volume of local anesthetic and spread of epidural anesthesia.
Regression analysis reveals a cubic polynomial equation that predicts number of anesthetized dermatomes based on volume injected.
The analysis included 120 women undergoing abdominal gynecologic surgery, each receiving varying volumes of mepivacaine.
The clinical significance of the cubic equation for epidural anesthesia remains uncertain due to data variability.

Kaneko et al. (1999) studied this question.

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