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September 10, 2025Genome biologyOpen Access

Oatk: a de novo assembly tool for complex plant organelle genomes

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Authors

CZChenxi ZhouZhejiang Chinese Medical UniversityMBMax R. BrownAnglia Ruskin UniversityMBMark BlaxterWellcome Sanger Institute

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Implication

Novel assembly tool improves organelle genome assembly in 195 plant species, highlighting structural complexity and heteroplasmy.

Key Points

  • This tool provides high-quality assemblies, enhancing the resolution of complex plant organelle genomes.
  • Demonstrated improvements in assembly accuracy over previous methods, particularly for large mitochondrial genomes.
  • Utilizes a syncmer-based assembler and profile-HMM database for efficient organelle identification.
  • Provides insights into DNA exchange and structural variations across diverse plant species.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68c19f7f54b1d3bfb60daa87https://doi.org/10.1186/s13059-025-03676-6
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