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September 10, 2025Journal of NeurochemistryOpen Access

Doxorubicin Induces a Senescent Phenotype in Murine and Human Astrocytes

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Authors

MMMariana MarquesLHLívia de Sá HayashidePAPedro Amorim

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Overview

This analysis reveals doxorubicin's effects on astrocytes in the CNS, highlighting age-related neurodegenerative implications.

Key Points

  • Doxorubicin treatment increases senescence markers in astrocytes, showing its potential in modeling age-related changes.
  • Research finds elevated levels of cytokines such as IL-6 and IL-1β, suggesting a strong pro-inflammatory response linked to senescence.
  • The methodology employed combines several cellular stressors to robustly induce senescence, enhancing the physiological relevance of astrocyte studies.
  • These findings provide a novel tool to explore neuroinflammation and neurodegeneration mechanisms in both human and murine astrocytes.

Cite This Study

Marques et al. (2025) studied this question.

synapsesocial.com/papers/68c19f9154b1d3bfb60dae2ahttps://doi.org/10.1111/jnc.70177
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Astrocyte Senescence Disrupts the Extracellular Mitochondrial Compartment and Compromises Bioenergetic Support to Human Neurons2026
  2. 2A comprehensive multi-omics signature of doxorubicin-induced cellular senescence in the postmenopausal human ovary.2024
  3. 3Network-Based Analysis of Human Astrocytes Links Aging to Neurodegenerative and Cardiovascular Diseases2025
  4. 4Astrocytes in Brain Aging and Neurodegeneration: Cellular Mechanisms and Interventional Strategies2026 · 2 citations
  5. 5Human aged astrocytes induce neurotoxicity in response to inflammatory stimuli2025