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September 10, 2025Physiological ReportsOpen Access

Blood lactate as a marker of exercise adaptation and fatigue in male mice with chronic heart failure

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Observational analysis showed blood lactate levels correlate with fatigue in CHF mice, highlighting exercise training's potential effects.

Blood lactate increased significantly at exhaustion among all groups, indicating its role as a fatigue marker.
In CHF mice, resting blood lactate levels were slightly higher but did not significantly correlate with exercise adaptation.
Exercise training resulted in a slight decrease in blood lactate during tests, suggesting potential benefits for aerobic capacity.
Elevated blood lactate at exhaustion may enhance the reliability of exercise tests in assessing chronic heart failure.

Wafi et al. (2025) studied this question.

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Observational analysis showed blood lactate levels correlate with fatigue in CHF mice, highlighting exercise training's potential effects.