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September 10, 2025TomographyOpen Access

Reliability of Automated Amyloid PET Quantification: Real-World Validation of Commercial Tools Against Centiloid Project Method

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Retrospective study evaluates automated tools against Centiloid method, suggesting reliable quantification for dementia diagnosis.

BTXBrain and SCALE PET showed excellent correlation with the Centiloid method, indicating high reliability.
MIMneuro displayed lower agreement, which highlights variability in automated tools for amyloid PET quantification.
Automated platforms maintained reliable trends in low-positive ranges, supporting their practicality in clinical settings.
Concordance with visual interpretation was strong, underscoring the tools' utility in dementia assessment.

Kang et al. (2025) studied this question.

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