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September 10, 2025Russian Journal of Pediatric Hematology and OncologyOpen Access

Complex endoscopic diagnosis of the gastrointestinal form of acute graft-versus-host disease in children who underwent allogeneic hematopoietic stem cell transplantation. Single-center study

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Authors

VLV. V. LozovayaOGO. A. GusarovaИКИ. О. Костарева

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Overview

Retrospective study finds comprehensive endoscopic examination improves diagnostic accuracy for GI aGVHD, suggesting better outcomes for pediatric patients.

Key Points

  • A comprehensive endoscopic examination confirmed GI aGVHD in 81.5% of suspected cases.
  • The diagnostic value of forceps biopsy for altered mucosa in GI aGVHD was 86.4%.
  • Sensitivity of combined endoscopic methods reached 88.9%, compared to 68.5% for colonoscopy alone.
  • Utilizing a comprehensive approach improves diagnosis, reinforcing the need for thorough examinations in suspected cases.

Cite This Study

Lozovaya et al. (2025) studied this question.

synapsesocial.com/papers/68c19f9c54b1d3bfb60db592https://doi.org/10.21682/2311-1267-2024-11-4-60-70
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endoscopic criteria for colonic mucosal damage in children with suspected acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation2024
  2. 2Endoscopic visualization of the ileum mucosa in the early diagnosis of acute graft-versus-host response after allogeneic stem cell transplantation in children2024
  3. 3Intestinal and Extraintestinal Findings of Graft-versus-Host Disease on CT: A Case Series with Radiological and Histopathological Correlations2024 · 5 citations
  4. 4Diagnostic prediction of gastrointestinal graft-versus-host disease based on a clinical- CT- signs nomogram model2024 · 3 citations
  5. 5Tissue-Based Transcriptomic Profiling of Gastrointestinal Graft Versus Host Disease Reveals Immune and MicroRNA Dysregulation2026