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September 10, 2025AntibioticsOpen Access

Characterization of Antibiotic Administration Factors Associated with Microbiome Disruption and Subsequent Antibiotic-Resistant Infection and Colonization Events in Acute Myeloid Leukemia Patients Receiving Chemotherapy

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Authors

SFSamantha FranklinTexas A&M University CRC. RamontCentre Hospitalier Universitaire d'Angers MBMaliha BatoolTexas A&M University

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Implication

Observational analysis identifies antibiotic use impacts microbiome and antibiotic-resistant infections in AML patients, suggesting caution in treatment choices.

Key Points

A greater number of unique antibiotic classes is linked to a loss of antibiotic resistance genes, suggesting a correlation with microbiome disruption.
Linezolid, an antibiotic used in treatment, showed a 30% reduction in risk of antibiotic-resistant colonization per additional day of administration.
The use of different antibiotics can influence the risk of antibiotic resistance gene expansion in patients undergoing chemotherapy for acute myeloid leukemia.
Although certain antibiotics may reduce microbial diversity, they do not always lead to an increase in antibiotic resistance gene events.

Cite This Study

Franklin et al. (2025) studied this question.

synapsesocial.com/papers/68c19fa854b1d3bfb60db73e https://doi.org/10.3390/antibiotics14080770

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Implication

Observational analysis identifies antibiotic use impacts microbiome and antibiotic-resistant infections in AML patients, suggesting caution in treatment choices.

Characterization of Antibiotic Administration Factors Associated with Microbiome Disruption and Subsequent Antibiotic-Resistant Infection and Colonization Events in Acute Myeloid Leukemia Patients Receiving Chemotherapy

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Implication

Key Points

Cite This Study

Characterization of Antibiotic Administration Factors Associated with Microbiome Disruption and Subsequent Antibiotic-Resistant Infection and Colonization Events in Acute Myeloid Leukemia Patients Receiving Chemotherapy

Discussion

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Implication

Key Points

Cite This Study

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