Cross-sectional research reveals low lymphocyte-high density lipoprotein ratio links to cognitive impairment in older adults, suggesting it as a potential biomarker.
Objective To explore the association between lymphocyte-high density lipoprotein ratio (LHR) and cognitive impairment in Chinese older adults. Methods This study included participants aged ≥65 years from the 2008 to 2014 waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Cognitive function was assessed using the Mini-Mental State Examination, with a score of less than 24 points considered indicative of cognitive impairment. Multiple logistic regression analysis and restricted cubic spline were applied to investigate the association between LHR and cognitive impairment. Results Of 3556 participants, 1625 (45.7%) suffered from cognitive impairment. Multivariate logistic regression analysis indicated that low LHR was associated with cognitive impairment [odds ratio (OR) = 1.34; 95% confidence interval (CI) = 1.11-1.62, P = 0.002]. Conclusions Lower LHR was associated with cognitive impairment in Chinese older people. This finding suggests LHR could serve as a novel and accessible biomarker for identifying high-risk aging populations.
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Yang et al. (2025) studied this question.
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