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September 10, 2025Chinese Medical JournalOpen Access

Role of neoadjuvant therapies in locally advanced colon cancer

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Authors

TCTiago Biachi de CastriaGLGabriel LenzGVGabriel Valagni

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Overview

Review reveals neoadjuvant chemotherapy enhances outcomes in locally advanced colon cancer, suggesting immunotherapy benefits for dMMR tumors.

Key Points

  • Neoadjuvant chemotherapy improves tumor downstaging and resectability in locally advanced colon cancer.
  • Trials like FOxTROT and NICHE demonstrate promising outcomes, particularly for dMMR tumors with immunotherapy.
  • Challenges in managing locally advanced colon cancer include progression during treatment and chemotherapy-related toxicities.
  • Personalized treatment strategies informed by MMR status are essential to maximize efficacy and minimize risks.

Cite This Study

Castria et al. (2025) studied this question.

synapsesocial.com/papers/68c1a11f54b1d3bfb60dbacchttps://doi.org/10.1097/cm9.0000000000003756
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Preoperative Strategies for Locally Advanced Colon Cancer2024 · 15 citations
  2. 2Systematic Review of Neoadjuvant Immunotherapy for Mismatch Repair Deficient Locally Advanced Colon Cancer: An Emerging Strategy2024 · 6 citations
  3. 3The safety and efficacy of immune checkpoint inhibitor in combination with FOLFOX as neoadjuvant/adjuvant therapy in patients with locally advanced colon cancer.2024
  4. 4Neoadjuvant immunotherapy combined with radiochemotherapy vs chemotherapy alone in pMMR colon cancers: The TORCH-C randomized phase 2 clinical trial.2026
  5. 5Neoadjuvant therapies ready to cure?2025