Gastrointestinal Stromal Tumour (GIST)

Introduction Gastrointestinal stromal tumors (GISTs) are the most frequent malignant mesenchymal lesions of the gastrointestinal tract believed to originating from the interstitial cells of Cajal. These tumors typically exhibits overexpression of the tyrosine kinase receptor, protein product of c‐KIT gene (KIT) CD 117.they may appear in GI tract and most frequently found in the stomach(60%) .  Objective: To analyze the clinical characteristics , diagnosis , treatment , approaches, recurrence, and survival rates of GISTS. In this case, series a total number of 3 patients, admitted and operated in the surgical department of PDU Medical College and Hospital .The age range of the patients was 50 to 70years. The cases were evaluated for symptoms ,tumor location ,size,diagnostic findings , surgical approach and outcomes. Out of 3 cases, 2 occurred in the stomach, 1 in jejunum.  Conclusion: GISTs are aggressive tumors, particularly when located in stomach . Diagnosis and treatment strategies depend on their size and location, surgical intervention remains the mainstay of treatment , with endoscopy playing a role in selected cases.