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September 10, 2025BiomoleculesOpen Access

Sitagliptin Mitigates Diabetic Cardiomyopathy Through Oxidative Stress Reduction and Suppression of VEGF and FLT-1 Expression in Rats

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Sitagliptin significantly reduced blood glucose levels and improved heart health markers in diabetic rats.
Administration of sitagliptin led to reduced inflammation and oxidative stress, indicating potential cardiac protection.
The study was conducted using a model of diabetic cardiomyopathy induced by streptozotocin in rats over 90 days.
Sitagliptin's effects highlight its potential to enhance vascular health and mitigate myocardial stress in diabetes.

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Animal study shows sitagliptin improves cardiac outcomes in diabetic rats, suggesting benefits for vascular health and oxidative stress management.

Alqahtani et al. (2025) studied this question.

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Animal study shows sitagliptin improves cardiac outcomes in diabetic rats, suggesting benefits for vascular health and oxidative stress management.