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This is a Literature Review study.

Unraveling the Translational Relevance of β-Hydroxybutyrate as an Intermediate Metabolite and Signaling Molecule

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This review examines β-hydroxybutyrate’s impact on metabolic disorders and neurodegenerative diseases, suggesting new therapeutic avenues.

BHB enhances mitochondrial function and reduces oxidative stress, promoting health during aging.
The review highlights BHB's influence on metabolism, inflammation, and muscle maintenance in chronic conditions.
Through GPCR activation, BHB shows potential for mitigating sarcopenia and neurodegenerative diseases.
Further research is necessary to establish clinical dosing and understand underlying mechanisms.

Pali et al. (2025) studied this question.

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This review examines β-hydroxybutyrate’s impact on metabolic disorders and neurodegenerative diseases, suggesting new therapeutic avenues.