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September 10, 2025International Journal of Molecular Medicine

Secretion of specific metabolites and changes in miRNA expression in murine osteoblastic cells exposed in vitro to α‑radiation

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Authors

SMSatoru MonzenHirosaki University YTYota TataraHirosaki University MCMitsuru ChibaHirosaki University

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Implication

Observational analysis identified significant alterations in osteoblastic cell secretion and miRNA expression, suggesting impacts on bone marrow microenvironment.

Key Points

α-Radiation exposure led to reduced clonogenic survival in osteoblastic cells, impacting their function.
Mass spectrometry analysis revealed alterations in six proteins and various lipid species following α-radiation exposure.
miRNAs such as miR-1895, miR-370-3p, and miR-188-5p were downregulated, indicating significant molecular changes.
Enrichment analysis highlighted pathways involved in transcriptional regulation and apoptosis, emphasizing the need for further exploration.

Cite This Study

Monzen et al. (2025) studied this question.

synapsesocial.com/papers/68c1a12754b1d3bfb60dc0b5 https://doi.org/10.3892/ijmm.2025.5602

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Implication

Observational analysis identified significant alterations in osteoblastic cell secretion and miRNA expression, suggesting impacts on bone marrow microenvironment.

Secretion of specific metabolites and changes in miRNA expression in murine osteoblastic cells exposed in vitro to α‑radiation

Discussion

Member takes

Implication

Key Points

Cite This Study

Secretion of specific metabolites and changes in miRNA expression in murine osteoblastic cells exposed in vitro to α‑radiation

Discussion

Member takes

Implication

Key Points

Cite This Study

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