Observational analysis shows reduced chromosomal abnormalities in Allium cepa cells treated with Olea europaea extract, suggesting potential protection against deltamethrin toxicity.
In this research, the potential protective effect of Olea europaea L. (olive) leaf extract (OE) against the genotoxic effects of deltamethrin, a widely used insecticide, on Allium cepa L. root cells was revealed. Allium root tip cells assay were used to determine this effect. Deltamethrin (DM) treatments generally showed a significant decrease in mitotic index (MI) values (DM 2x group 48 hrs treatment about 96%) and a significant increase in chromosomal abnormality rates (DM 2x group 48 hrs treatment about 8 times) compared to the control group. OE treatments were observed to reduce abnormality rates (OE 2.0g/L 24 h treatment resulted in approximately 32% reduction) while keeping MI close to the control level (OE 0.5g 24 hrs treatment resulted in approximately 15% reduction). The most remarkable improvement was recorded in the DM 1x+OE 2.0g/L 48 hrs group. MI value was 7.33±0.4 and abnormality rate was 4.3±0.4, showing a significant improvement compared to the Deltamethrin-only groups. These results support the notion that OE extract as a herbal bioactive agent may have potential protective effect against insecticide-induced genotoxicity.
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SEVİNÇ et al. (2025) studied this question.
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