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September 10, 2025Journal of Agricultural and Food Chemistry

Enhanced Production of Santalols by Engineering the Cytochrome P450 Enzyme to the Peroxisomal Surface in Yeast

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Santalol production reached 10.4 g/L, the highest reported, enhancing potential applications.
Initial modifications increased santalol titer to 0.45 g/L with a conversion rate of 36.2%, significantly improving output.
Engineering of the mevalonate pathway and enzyme targeting to peroxisomes led to 5.1-fold increase in santalene levels.
Increasing peroxisome quantity further boosted conversion rates to 60.6%, indicating optimized biosynthetic pathways.

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Implication

This study demonstrates improved santalol yields in Saccharomyces cerevisiae, suggesting potential for plant natural products production through peroxisomal targeting.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68c1a12d54b1d3bfb60dc44d https://doi.org/10.1021/acs.jafc.5c05047

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Implication

This study demonstrates improved santalol yields in Saccharomyces cerevisiae, suggesting potential for plant natural products production through peroxisomal targeting.

Enhanced Production of Santalols by Engineering the Cytochrome P450 Enzyme to the Peroxisomal Surface in Yeast

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Discussion

Implication

Cite This Study

Enhanced Production of Santalols by Engineering the Cytochrome P450 Enzyme to the Peroxisomal Surface in Yeast

Key Points

Discussion

Implication

Cite This Study

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