Clinical Effect of Diarrhea Stop Capsule in Patients with Acute Diarrhea

Introduction: Diarrhea remains a significant global health concern, particularly in developing countries. Herbal formulations have shown promise in managing acute and functional diarrhea with fewer side effects compared to conventional drugs. Objective: The aim study was to investigate the clinical efficacy and safety of Diarrhea Stop Capsule, a polyherbal formulation in patients with acute diarrhea. Methods: open-label, randomized clinical study of Diarrhea Stop Capsule was conducted for treatment of diarrhea in patients with diarrhea. 40 hospitalized patients with acute diarrhea. Patients were divided into 2 groups. Group1 consist of 30 Patients were received a single dose 2 capsules of Diarrhea Stop Capsule orally and Group 2 consist of 10 patients treated with metronidazole 500mg IV. Clinical parameters as stool frequency, consistency using the Bristol Stool Scale, abdominal pain and bloating, were assessed. These parameters were assessed before and after each 2 hours for six hours of oral Diarrhea Stop Capsule group2 and metronidazole IV group 1 for three days. Results: demonstrated significant improvement in stool frequency, consistency, abdominal pain and bloating after 2hours of single dose 2 capsules of Diarrhea Stop Capsule orally administration (group1). On other hand, group 2 was not significantly improved, as well as high significantly as compared with group1. Conclusion: Diarrhea Stop Capsule demonstrated significant clinical efficacy in reducing symptoms of acute diarrhea without adverse events. Its polyherbal composition provides a safe and effective option for short-term management of diarrhea.